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AntiAgeing BioCellular Rejuvenation

IGNOTINE ANTI-AGING

Many different Studies have shown that Ignotine is a major tool in the fight against aging and degenerative disease. It is found in all cells, but in higher quantities in muscles, heart, kidney and brain cells. As we age, optimum conversion from dietary sources becomes inefficient. In studies, the longer living animals had more of it in their cells. Ignotine is a naturally occurring product in our food. But with the passing of time it decreases, this is believed to be one of the primary factors leading to the aging process. The human body has an optimum design factor of over 120 years, but few people live beyond their 80’s. Ignotine, when introduced into the body's cells, has been shown to rejuvenate the cells; in essence, it is working as an anti-aging agent from within our cell structure.

Scientific research undertaken in Australia: To ascertain the effects of Ignotine on cultured human cells. What they did know were the results of decades of research on human cells and the well-defined pattern in the growth, development and aging of them, referred to as the “Hayflick Phenomenon”. Placed in a growth vat with a fluid rich in essential nutrients, cells from young donors will quickly begin to reproduce, forming colonies, which fill the vat and then stop reproduction, to prevent starvation. If half of these cells are removed from the container, the remaining cells will begin growing again to fill their environment. But this process only goes on so far. At each round of division, the cells are aging or becoming “senescent”. Senescent cells stop producing the right proteins from their DNA, losing the functions for which they were designed. The appearance of the cell culture takes on a degraded texture. (see photos A, B, C, below) Eventually, after about 60 divisions, the cells will stop reproducing and are just alive, inactive and waiting for death. This is the same process which happens in aging and deterioration of the skin.

Ignotine Rejuvenates Cells

Cultures of old, dying (senescent ) cells cannot be mistaken for younger cells, which are uniform in appearance and line up in parallel arrays. By contrast, senescent cells exhibit a grainy appearance and take on peculiar shapes and sizes. They lose the ability to organise themselves in a regular pattern. These striking changes are called the senescent phenotype. Ignotine has been shown to rejuvenate old, dying cells quickly restoring the juvenile phenotype (McFarland GA et al., 1999; McFarland GA et al., 1994).

Below are three photographs of human calls grown in culture.
 

 Photo A shows healthy Young Cells

Photo B shows Senescent (old) Cells

Photo C shows Senescent (old) Cells supplemented with L-Carnosine
(Compare Photo C against Photo A above)

The scientists raised lung and skin cells in one of two standard cell culture mediums. Then they kept half of the cells in the original medium, and transferred half to the same medium supplemented with Ignotine. The results were vivid and amazing. The cells in Ignotine not only had from 1 to 7 more population doublings, the cells themselves lived up to two thirds longer than the standard medium cells! Ignotine treated cells had far exceeded the Hayflick limit!

Further more, adding Ignotine to the cell medium made the cells younger! Scientists described the results as “striking effects on the cell morphology" (shape and structure). The cells grown in Ignotine-supplemented medium looked the same as they did when they were young even over time, yet the ones raised in the regular medium became damaged and irregular and finally broke apart.


The scientists took the old, damaged cells from the standard medium and put them into the Ignotine supplemented medium and this process was reversed by taking the Ignotine supplemented cells and putting them in ordinary medium. The once Ignotine treated cells rapidly degenerated into what would be their normal state, but the damaged, old cells from the normal medium were made younger again by the Ignotine . Quote:


“These cells showed a remarkable rejuvenation, with regard to their Morphology.. .and finally reached ages significantly greater than the control culture from which they were derived.”

Scientific experiments have since repeated, confirmed and expanded on the original results. They have shown that they could take regular cells, observe them age and put them in the Ignotine, observe them grow younger and switch them back and watch them age again. They propose that Ignotine is integral to cellular organization and function, optimizing longevity.


General properties and actions of Ignotine That have been Clinically Established

(1) It inhibits the activity of MAO B (monoamine oxidase B) which is an enzyme involved in breaking down some brain messengers (such as dopamine and serotonin). MAOB activity is known to increase production of the free radicals. Deprenyl, a drug used to treat people with Parkinson’s disease, works by inhibiting MAO B.)

(2) Ignotine enhanced memory functions of the brain cells and stopped the over stimulation of certain receptors... which in situations such as stroke can inhibit oxygen to the brain cells leading to cellular death.

(3) As people age, their rate of tearing down old, defective cellular proteins (proteolysis) slows down, which interferes with cellular function. Ignotine maintains proteolysis at more youthful levels in old cells. It also reacts with abnormal proteins, making it easier for the body to rid itself of them. In the first tests, it was noticed that one of the batches of normal medium cells had become contaminated with cancer cells. It was growing rapidly. When Ignotine was added to this dying population, the cell cultures became free of cancer cells! They tried it against seven different human cancers and every one showed the same result. It seems that as beneficial as Ignotine is to normal cells… it was selectively toxic to human cancer cells!

(4) Ignotine enhances various aspects of immunity and protects cells against damage from a variety of toxins produced in the body as a part of normal metabolism such as the lipid peroxidation product malondialdehyde; the cancer-causing glycation product methylglyoxal hypochlorite, a deadly substance made by cells of the immune system to kill off invading pathogens, but also toxic to the body’s own cells; formaldehyde’ and the amyloid beta-peptide, which forms the seed of the plaques associated with Alzheimer’s. Ignotine also prevents the development of amyloid into full-fledged plaques.

(5) Ignotine protected cellular DNA better than any other antioxidant (Vit E, Vit C, NAC etc) under the stress of toxic levels of oxygen. In fact it was the only substance which did.

(6) Ignotine is a highly versatile antioxidant capable of neutralizing a large range of free radicals (superoxide, singlet oxygen, hydrogen peroxide and both peroxyl and hydroxyl radicals). Further, it has indirect antioxidant powers through chelation of pro-oxidant metals and the prevention of the destruction of the antioxidant enzyme superoxide dismutase. These qualities give it a place in mercury and other heavy metal detoxification.

(7) In some cases, Ignotine changes gene expression in cells exposed to it, including increasing the expression of vimentin, a protein involved in maintaining the integrity and complex internal structure of the cell.

(8) Ignotine also protects against the formation of Advanced Glycation endproducts (AGE’s), proteins warped by sugar (glycated). When a protein becomes glycated, it results in the loss of that protein’s function, loss of flexibility, atherosclerosis, abnormal cellular signalling, inflammation, the complications of diabetes, and aspects of the aging process.
 

How much Ignotine should be taken as a health supplement?

Ignotine starts to become effective from 900-1000mgs. So one gram a day is advised for general maintenance but in times of extra need two to three grams a day is recommended, such as an elderly person with health problems. Also, body weight is another factor which needs to be taken into consideration; people with larger body masses require more than smaller framed people. The recommendations above are based on an average person around 60-70Kg.  There are no adverse affects from taking too much as the excess is expelled naturally When it is broken down by the enzymes in the body it changes into two other essential nutraceuticals. The best way to administer it to the body is in small amounts, little and often. The best way that we have found of achieving this is to mix the daily amount in a litre bottle of mineral water and then sip it regularly throughout the day.

General Properties of Ignotine as shown by scientific studies

Protection of skin: Ignotine helps prevent skin collagen cross-linking which leads to loss of elasticity, wrinkles.

Cell Rejuvenation: Ignotine has the fantastic ability to rejuvenate cells approaching old age and restoring normal appearance and extending their lifespan.

Wound Healing: Ignotine is able to rejuvenate connective tissue cells and therefore improve wound healing.

Brain Protection: Ignotine protects the microvas culature of the brain from the development of plaque that can contribute to senility and Alzheimer’s disease.

Antioxidant: Ignotine helps to eliminate the most destructive of free radicals, the hydroxyl radical, as well as super oxide, singlet oxygen, and the peroxyl radical.

Improved Calcium Response: Ignotine helps the heart muscle to contract more efficiently through improvement of calcium response in heart myocytes.

Cellular DNA Protection: Ignotine protects the cells DNA from damage that accumulates with age.

Anti-Carbonylation: Carbonylation is a pathological step in the deterioration of the body’s proteins with age and Ignotine is the most effective anti-carbonylation agent yet discovered.. Ignotine helps to prevent loss of elasticity, wrinkles, and loss of the extracellular matrix.

Ignotine occurs naturally in the body and food chain Nerve and muscle cells contain high levels of Ignotine. You are born with high levels of Ignotine in your body but unfortunately it decreases with age leaving you vulnerable to illness and the effects of aging. The good news is that you can now replace Ignotine naturally with a daily supplementation.

Other effects of Ignotine that have been observed and studied:

* Lowers blood pressure * Improves immune function * Reduces incidence of peptic ulcers * Converts body fat into energy * Improves anaerobic athletic performance * Protects the body against alcohol damage *Ameliorates congestive heart failure. * Acts as a of zinc and copper regulator in nerve cells., helping to prevent over stimulation by these neuroactive minerals/trace elements.

"I have been a diabetic for a number of years and take insulin twice a day. My blood sugar level has been inconsistent which is usually high then low, but should be 7-2 or there abouts. Since I have taken Ignotine my blood sugar has improved to what it should be.

As for the Eye Drops, they have also helped my eyes as I had a slight shadow at the back of my eyes a year ago. When I got my diabetic check-up, it was all clear."

Kenneth Forrester, Scotland

A picture paints a 1000 words!

In 1996 Professor Steven Gallant and Professor Alexander Boldyrev, the world's leading authorities in their field, started an experiment to see if Ignotine would have any benefits on a large group of mice.

The photos below clearly demonstrate that some of the deterioration that occurs with aging can be prevented by supplementing the diet with Ignotine. The two mice shown are brothers of identical age, but the Ignotine supplemented mouse had a far healthier appearance, a lot better quality of life, and went on to live 20%, that's a fifth, longer than the other! And this was not a one off experiment, it was reproduced on many more mice.

Extracts from an article by Roger Mason: Ignotine Is An Effective Supplement

It is important to realize that Ignotine naturally occurs in our bodies (mostly in our muscles) and in common food. The levels of Ignotine fall as we age, especially in our hearts. The brain depends of high levels of Ignotine for optimum function and Ignotine is being investigated as a preventative for Alzheimer’s. It is a strong anti-oxidant, which fights dangerous free radicals. The most important use may be to be enhancement of heart health generally. Coronary heart disease is the biggest killer of adults by far, and everything we can do to make our hearts stronger helps guarantee a longer life. This qualifies Ignotine clearly as a life extension agent. It is also very critical in cell regeneration and the function of fibroblasts. “Cellular aging” is a key to understanding the power of Ignotine as it seems to very much slow down the aging of many cells in our bodies. Many of the studies so far have only been on cell cultures and lab animals, but more and more human studies are being done. Let’s take a look at just a few of the studies. In the Russian journal Biokhimiya v.57, (1992) scientists at Moscow State University did a review with 52 references. They concluded that Ignotine is a, “perspective immunomodulating tool which has many applications in medicine,” due in part to its powerful antioxidative properties. Also in the same journal another review was published with 25 references on the history and actual physiological actions of Ignotine.

At Ohio University doctors published a study in Comprehensive Biochemistry and Physiology v. 103B, (1992). Using rats they found Ignotine levels in the heart and skeletal muscles fell over 40% as they aged and were 40% lower in rats with high blood pressure. Heart muscle showed a dramatic decline. The same has basically been found in humans as well and the implications for heart metabolism are clear here. These same authors published a second study in Biochemical Society Transactions v. 23 (1995). Again, they showed the sharp decrease in Ignotine in the heart and skeletal muscles as they aged, especially when high blood pressure is a factor. They also found that exercise was vital to keep Ignotine levels high. It is clear that our epidemic rates of hypertension may benefit from Ignotine supplementation. More studies will be reviewed in the future on high blood pressure and Ignotine supplementation.

At King’s College in London doctors published a stunning review of the benefits, functions and therapeutic applications of Ignotine with 252 references in Molecular Aspects of Medicine v.13 (1992). It would take days to wade through such a review, but you can see just how documented the therapeutic applications of Ignotine are with 252 references in just one review at such a prestigious college. This same college later was granted a World Patent (meaning the European Community) for helping relieve diabetes with Ignotine supplementation. Diabetes and blood sugar problems are now affecting our children as well as adults.

In the journal Nutrition Research v. 14, (1994) researchers at the University of Quebec in Canada found that dogs given Ignotine in their food regulated their insulin and glucagon secretion by affecting the pancreas. This has obvious potential for our extreme rates of diabetes and other blood sugar problems.

In the Russian Journal Byull. Eksp. Biol. Med. doctors at the Omsk Medical Institute studied rats by reviving them from induced death. They gave them injections to kill them, revived them and then injected half of them with Ignotine. The ones given the Ignotine not only had a higher survival rate, but less damage from being clinically dead for about five minutes. You may not like studies such as this, but much was learned from it.

At the School of Medicine in Kawasaki, Japan doctors published a study in the Japanese Journal of Physiology v. 45, (1995). Using rats they found that Ignotine is very important to physical endurance and exercise. This is due to the large amount of Ignotine contained in both the skeletal muscles and the heart muscle. A World Patent (European Community) was issued in 1990 for using Ignotine for improving athletic performance, endurance, fatigue and treating muscular disorders.

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